(CA-125), human epididymis protein 4 (HE4), the risk of malignancy index (RMI), and the risk of ovarian malignancy algorithm (ROMA) in the diagnosis of ovarian cancer in patients with ovarian lesions discovered during their preoperative work-up

Patient from control group underwent surgery for unexplanied infertility. The percentage of Treg and Th17 , NKT in peripheral blood and the tissue was assessed using the flow cytometry method according to the manufacturer's instructions. The ROMA index was calculated according to the levels of HE4 and CA-125 in serum.

At all premenopausal women was calculated ROMA1 index and at all postmenopausal women ROMA2 index. 2019-04-01 · Those data suggest that CA-125 and HE4 serum levels, and ROMA were increased with the development of ovarian cancer. Besides that, higher serum CA-125 and HE4 levels, as well as ROMA were found in all types of malignant tumor comparing with those in the corresponding type of benign tumor, but the degrees of increases were different. Tumour marker sensitivity in ovarian cancer was 79.3% for HE4, 82.9% for CA 125 and 90.1% for ROMA. Both tumour markers, HE4 and CA 125 were related to tumour stage and histological type, with the Chi L, Zhouxiaoying, Huangruiyu, et al. Diagnostic value of serum HE4, CA125, and ROMA index in ovarian cancer.

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Sponsor stated that there has been no modification of assay methods for HE4 EIA and ARCHITECT CA 125 II for used in the calculation of the ROMA score. CA 125, HE4, and ROMA exhibiting maximum Youden index were determined, respectively, as the optimal cutoffs, and sensitivity and specificity were evaluated by applying those cutoffs. Results: In benign diseases, CA 125 significantly increased in patients with uterine myoma, adenomyosis, endometrial pathology, or endometriosis, but HE4 only increased in patients with adenomyosis. HE4 + CA-125 rizikó becsléssel (ROMA-index) Élettani, kórélettani háttér.

CLINICAL SCIENCE. A comparison of CA125, HE4, risk ovarian malignancy algorithm (ROMA), and risk malignancy index (RMI) for the classification of ovarian 

CAS Article Google Scholar 67. Sandri MT, Bottari F, Franchi D, et al. Comparison of HE4, CA125 and ROMA algorithm in women with a pelvic mass: correlation with pathological outcome. The risk of ovarian malignancy algorithm (ROMA) incorporates cancer antigen 125 (CA125), human epididymal protein 4 (HE4), and menopausal status to assign women that present with an adnexal mass into a high-risk or low-risk group for finding an ovarian malignancy.

Aim . This study compared the diagnostic performance of the Risk of Ovarian Malignancy Algorithm (ROMA) and HE4 and CA125 for the presurgical differentiation of adnexal tumors. Material and Methods . This prospective study included 302 patients admitted for surgical treatment due to adnexal tumors. The ROMA was calculated depending on CA125, HE4, and menopausal status. Results.

This calculation combines the results of HE4, CA-125, and a woman's menopausal status into a numerical score. 2020-04-25 2019-09-06 Risk of Ovarian Malignancy Algorithm (ROMA) Food Control.

The premenopausal calculation formula of the ROMA index was: 12+2.38 x LN(HE4)+0.062 6 x LN(CA -125). MDCalc loves calculator creators – researchers who, through intelligent and often complex methods, discover tools that describe scientific facts that can then be applied in practice.
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The ROMA performed by LabCorp employs the Roche Elecsys HE4 and CA 125 assays as specifically indicated in the FDA-cleared manufacturer’s package insert.

Serum HE4 and CA-125 reference range was <140 pmol/l and <35 U/ml, respectively. ROMA index calculation. The ROMA index was calculated according to the levels of HE4 and CA-125. HE4 and CA-125 values were input to the ovarian cancer risk assessment software, followed by automatic calculation of the corresponding ROMA index.
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Połączenie CA 125 i HE4 w algorytmie ROMA zwiększa skuteczność wykluczenia nabłonkowych nowotworów jajnika we wczesnym stadium zarówno przed, jak i po menopauzie. Algorytm ROMA wykazuje 93,8% czułość i 75% swoistość w wykrywaniu złośliwych nowotworów nabłonkowych jajnika [26] .

ROMA ™ calculator - Aid in assessing the risk of ovarian cancer in women with a pelvic mass. You appear to be using incognito/private browsing mode or an ad blocker, which may adversely affect your experience on the site.

CA125 and HE4 cut-offs were 35 U/ml and 70 pmol/L, respectively. Results: HE4 had significantly higher concentrations in ovarian cancer than benign gynecologic disorders (p < 0.005). Tumor marker sensitivity in ovarian cancer was 78% for HE4, 63% for CA125, and 88% for ROMA index at 95% specificity.

Home > Esami di laboratorio > Marcatori tumorali > Indice Roma. L' Indice Roma (Roma index) prende in considerazione i livelli dei marcatori tumorali Ca-125 e He4 e mediante un algoritmo (12+2.38 × LN(HE4)+0.062 6 × LN(CA-125)) esprime un valore che può darci delle indicazioni di aiuto per l'accuratezza della diagnosi in caso di carcinoma ovarico. 2021-02-20 · The second aim was to study the advantages HE4, cancer antigen 125 (CA125) and ROMA index for distinguishing between benign and malignant tumors. Aware of the age distribution of ovarian cancer, we focused on postmenopausal patients.

The premenopausal calculation formula of the ROMA index was: 12+2.38 x LN(HE4)+0.062 6 x LN(CA -125). MDCalc loves calculator creators – researchers who, through intelligent and often complex methods, discover tools that describe scientific facts that can then be applied in practice. These are real scientific discoveries about the nature of the human body, which can … 2019-03-27 The sensitivity of the ROMA index was higher (P<0.01) with detection of HE4 and CA-125. In the ovarian cancer group, the areas under ROC curves of ROMA, HE4 and CA-125 were 0.994, 0.990 and 0.941, respectively. The specificity and positive predictive value of HE4 in the premenopausal ovarian cancer group reached 98.36 and 95%, respectively.